Simpsons opening by Michal Socha
This just might be the greatest Simpsons couch gag opening of all time. Created by Polish animation artist Mical Socha, the minute-long scene follows the family on a trippy journey through a Hellish version of Homer's body. It calls to mind alot of classic WWII-era cartoons as well as the 1960's graphic design work of Saul Bass, but it still incredibly fresh and new. See for yourself:
Here's one more from Socha, entitled Click: